Fig. 5: Knockdown of KIF15 may inhibit prostate cancer development through the PI3K/Akt signaling pathway. | Cell Death Discovery

Fig. 5: Knockdown of KIF15 may inhibit prostate cancer development through the PI3K/Akt signaling pathway.

From: Knockdown of KIF15 suppresses proliferation of prostate cancer cells and induces apoptosis through PI3K/Akt signaling pathway

Fig. 5

A A KEGG analysis was performed on genes with co-expression patterns with KIF15 obtained by coexpedia database. B The expression of several key proteins in the PI3K/Akt signaling pathway was detected in DU 145 cells with or without KIF15 knockdown. C The protein levels of Akt, p-Akt, PI3K, p-PI3K in shCtrl and shKIF15 DU 145 cells with or without treatment of Akt activator SC79 (10 μM) were detected by western blot analysis. D&E, The cell proliferation (D) and cell apoptosis (E) of shCtrl and shKIF15 DU 145 cells with or without treatment of Akt activator SC79 (10 μM) were detected by CCK8 assay and flow cytometry, respectively. F The expression of KIF15, p-PI3K, and p-Akt was detected in clinical specimens by IHC. Data were shown as mean with SD. *P < 0.05, ** P < 0.01.

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