Fig. 2: Down-regulated PGC-1α expression is associated with increased oxidative stress in the liver of mice at the early stage of hepatic I/R injury. | Cell Death Discovery

Fig. 2: Down-regulated PGC-1α expression is associated with increased oxidative stress in the liver of mice at the early stage of hepatic I/R injury.

From: PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury

Fig. 2

A H&E and immunohistochemistry analyses of 3’-nitrotyrosine and PGC-1α expression in liver tissues of mice at 0, 6, 12 and 24 h post hepatic I/R. B, C Western blot and RT-qPCR analyses of the relative levels 3’-nitrotyrosine and PGC-1α protein expression (B), and PGC-1α mRNA transcripts in liver tissues of mice at indicated time points post hepatic I/R (C), respectively. D, E TSA treatment partially rescued PGC-1α mRNA (D) and protein (E) levels in liver tissues of mice at 6 h post hepatic I/R. Data are representative images or shown as mean ± SD of each group (6–10/group) from at least three separate experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page