Fig. 3: TSA treatment preserves PGC-1α expression to mitigate oxidative stress, inflammation and liver injury in mice at early time post I/R. | Cell Death Discovery

Fig. 3: TSA treatment preserves PGC-1α expression to mitigate oxidative stress, inflammation and liver injury in mice at early time post I/R.

From: PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury

Fig. 3

Liver tissues were harvested from the indicated groups of mice at 6 h post hepatic I/R. A RT-qPCR analyses of the relative levels of SOD1, SOD3 and NRF2 mRNA transcripts. B, F Western blot analyses of the relative levels of 3’-nitrotyrosine (B), TNF-α and IL-6 (F) protein expression in liver tissues of mice. C H&E staining. D The levels of serum ALT. E RT-qPCR analysis of the relative levels of TNF-α and IL-6 mRNA transcripts in liver tissues from the indicated groups of mice at 1, 3 and 6 h post hepatic I/R. Data are representative images or shown as mean ± SD of each group (6–10/group) from at least three separate experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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