Fig. 7: PTP4A1 participates in mitochondrial metabolic reprogramming by promoting the degradation of ACO2 in OSCC cells. | Cell Death Discovery

Fig. 7: PTP4A1 participates in mitochondrial metabolic reprogramming by promoting the degradation of ACO2 in OSCC cells.

From: PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming

Fig. 7

A mRNA expression of ACO2 in OSCC cells transfected with PTP4A1 measured via RT-qPCR. B ACO2 expression in OSCC cells transfected with sh-PTP4A1 or PTP4A1 measured via western blotting. C Seahorse assays showing the oxidative consumption rate (OCR) in OSCC cells transfected with PTP4A1. D Seahorse assays demonstrating extracellular acidification rates (ECAR) in OSCC cells transfected with PTP4A1. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control.

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