Fig. 4: DSE enhances the antitumor immune microenvironment. | Cell Death Discovery

Fig. 4: DSE enhances the antitumor immune microenvironment.

From: DSE inhibits melanoma progression by regulating tumor immune cell infiltration and VCAN

Fig. 4

A Analysis of immune infiltration scores in TCGA human melanoma patients; B Correlation analysis of immune infiltration scores with DSE expression levels; C Subcutaneous inoculation of B16 cells into C57/B6 mice and collection of lymphocytes infiltrating within the tumor for flow analysis of CD4+ and CD8+ T cell ratios (n = 5 mice, mean ± s.e.m. **P < 0.01); D Flow analysis of GZMB in CD8 + T cells, TNF and IFNG expression levels in CD8+ T cells (n = 5 mice, mean ± s.e.m. **P < 0.01); E Flow analysis of PD-1, TIM-3 and LAG-3 expression levels in CD8+ T cells (n = 5 mice, mean ± s.e.m. **P < 0.01).

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