Fig. 7: DSE regulates melanoma proliferation, invasion and migration through VCAN.
From: DSE inhibits melanoma progression by regulating tumor immune cell infiltration and VCAN
A CCK8 assay to analyze the cell viability of A2508 cells overexpressing DSE and knocking out VCAN (mean ± s.e.m. **P < 0.01); B A2508 cells overexpressing DSE and knocking out VCAN were injected into nude mice to observe tumor growth; (n = 4 mice, mean ± s.e.m. **P < 0.01 and ***P < 0.001); C tumor weight in B (n = 4 mice, mean ± s.e.m. **P < 0.01); D Transwell assay analyzing DSE overexpressing and VCAN knockout Invasion and migration of A2508 cells (mean ± s.e.m. **P < 0.01); E Tail vein injection of cells overexpressing or knocking out DSE into nude mice to analyze lung metastasis (n = 4 mice, mean ± s.e.m. **P < 0.01 and ***P < 0.001). Data are representative of three (A–D) independent experiments.
