Fig. 6: Knockdown of METTL3 increased the Rituximab sensitivity of Farage/R cells. | Cell Death Discovery

Fig. 6: Knockdown of METTL3 increased the Rituximab sensitivity of Farage/R cells.

From: METTL3-mediated m6A methylation of C1qA regulates the Rituximab resistance of diffuse large B-cell lymphoma cells

Fig. 6

A–C METTL3 and C1qA expression in Farage/R cells with METTL3 knockdown (R-shMETTL3) and in control cells (R-shCtrl). D The levels of m6A-modified C1qA. E Cell survival rates and the IC50 value of Rituximab. F Cell proliferation under conditions of treatment with 20 μg/mL Rituximab was detected by the colony formation assay. G C3 chains expressed during treatment with 20 μg/mL Rituximab were detected by western blotting. H The proportions of apoptotic cells during treatment with 20 μg/mL Rituximab were detected by flow cytometry. ***p < 0.001, ### p < 0.001.

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