Fig. 1: Overview of mobilizing CTLs as a senolysis strategy. | Cell Death Discovery

Fig. 1: Overview of mobilizing CTLs as a senolysis strategy.

From: Healthy aging—would cytotoxic T lymphocytes stand out?

Fig. 1

Upper left: Targeted on the HCMV-gB (human cytomegalovirus glycoprotein B) antigen presented by HLA-II, the natural clearance of SnCs in women’s skin tissue is carried out prominently by CD4+ CTLs. Upper right: Immune checkpoint blockade (ICB) of PD-1 on CD8+ CTLs lowers the chance of immune evasion of SnCs in mice and human fibroblast cell line (hHCA2). Bottom: Artificially modified CAR T cells with senolysis function in mice. Created with BioRender.com.

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