Fig. 2: PDK4 expression decreases in skin wound tissues and dermal fibroblasts of diabetic mice and patients. | Cell Death Discovery

Fig. 2: PDK4 expression decreases in skin wound tissues and dermal fibroblasts of diabetic mice and patients.

From: PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway

Fig. 2

A Immunohistochemical analysis of PDK4 in skin wound tissues of diabetic mice or control group on day-10 after wound (n = 4). B Immunofluorescence double staining of PDK4-expressing (red) Vimentin+ cells (green) in skin wound tissues of diabetic mice or control group (scale bar, 20 μm). C PDK4 level detected by RT-qPCR in human skin wound tissues (n = 12, 14 respectively) D Representative Western blot images analyzing PDK4 in in human skin wound tissues. E PDK4 expression levels reported in GSE49566 (high-throughput transcriptomics data) in dermal fibroblasts of normal or diabetic patients. Data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant.

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