Fig. 4: PDK4 overexpression inhibits HDFs high-glucose-induced senescence. | Cell Death Discovery

Fig. 4: PDK4 overexpression inhibits HDFs high-glucose-induced senescence.

From: PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway

Fig. 4

A, B RT-qPCR and western blot analysis of PDK4 in different groups of HDFs (n = 3). C SA-β-GAL staining images of different groups of HDFs (n = 3). D Senescence markers and SASP-related protein detected by western blot in HDFs (n = 3). E Cell proliferation assessed by cell counting kit-8 assay (n = 3, **P < 0.01, ***P < 0.001, compared to the Con group; ##p < 0.01, ###p < 0.001, compared to the HG + LV-NC group;). F Transwell assay images and quantitative analysis of the migration of HDFs (n = 3, scale bar, 200 μm). The data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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