Fig. 8: PDK4 overexpression promotes YAP nuclear translocation and dephosphorylation of JNK in diabetic mice. | Cell Death Discovery

Fig. 8: PDK4 overexpression promotes YAP nuclear translocation and dephosphorylation of JNK in diabetic mice.

From: PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway

Fig. 8

A Quantitative analysis of the MDA in skin wound tissues (n = 4). B p-YAP, YAP, CTGF, p-JNK, and JNK detected by western blot in skin wound tissues (n = 4). C Level of YAP detected by western blot in cytoplasmic and nuclear extraction. Histone H3 was used as a nuclear internal reference, and β-tubulin was used as a plasma reference (n = 4). D Concise model of PDK4 in inhibiting HDFs senescence and accelerating wound healing. Data are shown as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant.

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