Fig. 4: ESRP1 cause a wide range of AS events in gastric cancer cells.
From: ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer
A Heatmap of DEGs between SGC7901 control (oeVector) and ESRP1 overexpression (oeESRP1) cells in RNA sequencing. B Volcano plot of upregulated and down-regulated DEGs in RNA sequencing. C Gene ontology (GO) enrichment analysis of down-regulated DEGs in oeESRP1 gastric cancer cells. D Schematic diagram of alternative splicing types. ES: exon skip. A3SS: alternative 3’ splice site. A5SS: alternative 5’ splice site. MXE: Mutually exclusive exons. 5pMXE: MXE + alternative 5’ promoter. 3pMXE: MXE + alternative polyadenylation site. E Histogram showing the number of different alternative splicing types. F Heatmap showing the top AS events in SGC7901 oeESRP1 gastric cancer cells. Top AS events were set as events with splicing counts > 50 and the difference AS ratio between groups > 0.2. Color of the ruler was displayed as AS ratio. G GO enrichment analysis of the differentially alternative splicing genes in SGC7901 oeESRP1 cells. H KEGG analysis of the differentially alternative splicing genes in SGC7901 oeESRP1 cells.
