Fig. 2: Knockout of CHEK2 selectively induces proliferation arrest, cell cycle blockade, and senescence in HCC cells with TP53 mutation. | Cell Death Discovery

Fig. 2: Knockout of CHEK2 selectively induces proliferation arrest, cell cycle blockade, and senescence in HCC cells with TP53 mutation.

From: CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma

Fig. 2

A–C Single-gene GSEA of low and high CHEK2 groups in the TCGA, ICGC, and GAO et al. databases. D–G Colony, Edu, cell cycle and β-gal staining of control, sgCHEK21# and sgCHEK22# groups in LM3, Huh7, and hepG2 cell lines (n = 3). H–K Western blot results of control, sgCHEK21# and sgCHEK22# groups in LM3, Huh7, and hepG2 cell lines.

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