Fig. 6: Combining Nultin-3 and knockout of CHEK2 could influence several biological processes of HCC via mitochondrial ATP.
From: CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma
A–D β-gal staining, colony, Edu and cell cycle of control, sgCHEK21# + Nultin-3 and sgCHEK21# + Nultin-3 + Metformin groups in LM3, Huh7 cell lines (n = 3). E–G Western blot results and apoptosis assays of control, sgCHEK21# + Nultin-3 and sgCHEK21# + Nultin-3 + Metformin groups in LM3, Huh7 cell lines. H–Q ATP level, NADH+/NADH ratio, transmission electron microscopy, JC1 and MitoSox level of control, sgCHEK21# + Nultin-3 and sgCHEK21# + Nultin-3 + Metformin groups in LM3, Huh7 cell lines (n = 3).
