Table 1 SMR association between expression of genes and HCC outcomes.

GWAS					eQTL			SMR			HEIDI
Dataset	Genes	Beta	Se	P-value	Beta	Se	P-value	Beta	Se	P-value	P-value	nsnp
ieu−b−4953	CHEK2	0.26524	0.112938	0.0188469	0.0597826	0.00810063	<0.0001	4.43674	1.9825	0.02522383	0.2650548	20
	GOLPH3	1.44293	0.470894	0.00218231	−0.760142	0.0256463	<0.0001	−1.8982	0.62278	0.002303777	0.07860278	20
	PEX10	−0.2620	0.119524	0.0283323	0.132862	0.00979605	<0.0001	−1.9725	0.911291	0.03042141	0.07117842	20
	PLCH2	0.42379	0.142179	0.00287558	0.703135	0.0110791	<0.0001	0.60272	0.20243	0.002906472	0.1571539	20
	RP3-395M20.2	0.42379	0.142179	0.00287558	0.28422	0.0236051	<0.0001	1.4911	0.515344	0.003810954	0.4889532	17
	RP3-395M20.3	0.42379	0.142179	0.00287558	0.180591	0.0187417	<0.0001	2.34674	0.824108	0.004404904	0.5993256	9
ICD10 C22.0	CHEK2	0.00005	0.00001	0.00633099	0.0597826	0.00810063	<0.0001	0.00086	0.000117	<0.0001	1	20
	GOLPH3	−0.0001	0.000062	<0.00001	−0.189354	0.0118197	<0.0001	0.00067	0.000331	0.04263156	0.138445	8
	PEX10	−0.0001	0.000053	<0.00001	0.132862	0.00979605	<0.0001	−0.0011	0.000409	0.00384419	0.907163	20
	PLCH2	0.00014	0.000063	<0.00001	0.703135	0.0110791	<0.0001	0.00020	0.000089	0.01967015	0.950303	20
	RP3-395M20.2	0.00014	0.000063	<0.00001	0.28422	0.0236051	<0.0001	0.00051	0.000225	0.02193467	0.2166663	12
	RP3-395M20.3	0.00014	0.000063	<0.00001	0.180591	0.0187417	<0.0001	0.00081	0.000359	0.0232958	0.2713227	8

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