Fig. 6: NMDAR activation-mediated VEC ferroptosis is regulated by the PP2A-AMPK-HMGB1 pathway in vivo.
From: NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis
A PP2A activity in vascular tissue after treatment with LB100, AICAR, MK-801, and GLY in the presence or absence of NMDA or GLU in vivo. B Western blot image and (C) quantification of p-PP2A, PP2A, p-AMPK, AMPK, and HMGB1 in GLU and/or LB100-, AICAR-, MK-801-, and GLY-treated mice. D Western blot image and (E) quantification of p-PP2A, PP2A, p-AMPK, AMPK, and HMGB1 in GLU and/or LB100-, AICAR-, MK-801-, and GLY-treated mice. *P < 0.05, **P < 0.01 and ***P < 0.001 vs control; #P < 0.05 and ###P < 0.001 vs NMDA; &P < 0.05, &&P < 0.01 and &&&P < 0.001 vs GLU.
