Fig. 3: Retinal ganglion cell (RGC) loss in MYOCS341P transgenic mice. | Cell Death Discovery

Fig. 3: Retinal ganglion cell (RGC) loss in MYOCS341P transgenic mice.

From: Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation

Fig. 3

A Hematoxylin and eosin (H&E) staining of the retina in MYOCS341P transgenic mice (n = 12) at 3, 8, and 11 months old and WT littermates at 3 months old (n = 3). GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer. B Statistical analysis of retinal thickness experiments illustrated in (A). *P < 0.05. C Statistical analysis of retinal NFL thickness experiments illustrated in (A). NFL: nerve fiber layer. ***P < 0.001. D Whole-mount retinal preparations were stained with RBPMS antibody in MYOCS341P transgenic mice and WT littermates at 3, 8, and 11 months of age. E Statistical analysis of RGC numbers in MYOCS341P transgenic mice and WT littermates at 3 months (WT: n = 6 vs MYOCS341P transgenic mice: n = 6), 8 months (WT: n = 6 vs MYOCS341P transgenic mice: n = 5), and 11 months (WT: n = 6 vs MYOCS341P transgenic mice: n = 5) of age, normalized to the WT group. ns, not significant; *P < 0.05.

Back to article page