Fig. 4: Impaired visual function in MYOCS341P transgenic mice. | Cell Death Discovery

Fig. 4: Impaired visual function in MYOCS341P transgenic mice.

From: Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation

Fig. 4

A Schematic diagram of the optomotor response experimental process (left) and the maximum spatial frequency in MYOCS341P transgenic mice and WT littermates aged 3 months (WT: n = 12 vs MYOCS341P transgenic mice: n = 10), 8 months (WT: n = 6 vs MYOCS341P transgenic mice: n = 8), and 11 months (WT: n = 8 vs MYOCS341P transgenic mice: n = 8). ns, not significant; *p < 0.05. B Representative a-wave, b-wave, and PhNR in electroretinograms. C Waves of scotopic flash stimulation at 0.01 (left), 20 cd.s/m2 (middle), and photopic flash stimulation of 20 cd.s/m2 (right) in 3-month-old MYOCS341P transgenic mice and age-matched WT littermates. D Waves of scotopic flash stimulation at 0.01 (left), 20 cd.s/m2 (middle), and photopic flash stimulation of 20 cd.s/m2 (right) in 8-month-old MYOCS341P transgenic mice and age-matched WT littermates. E Analysis of b-wave under scotopic flash stimulation at 0.01 cd.s/m2 (left), a-wave (middle) and b-wave (right) under scotopic flash stimulation at 20 cd.s/m2 in 3- and 8-month-old MYOCS341P transgenic mice and age-matched WT littermates. F Analysis of a-wave (left), b-wave (middle), and PhNR (right) amplitudes under photopic stimulation at 20 cd.s/m2 in 3-and 8-month-old MYOCS341P transgenic mice and age-matched WT littermates. *P < 0.05.

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