Fig. 1: Summary of distribution of human-α-synuclein (hu-α-syn) pathology in young and aged mice following the intra-striatal injection of hu-α-syn preformed fibril (PFF). | Cell Death Discovery

Fig. 1: Summary of distribution of human-α-synuclein (hu-α-syn) pathology in young and aged mice following the intra-striatal injection of hu-α-syn preformed fibril (PFF).

From: Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction

Fig. 1

A The schema of young and aged mice intra-striatally injected with hu-α-syn PFF and analyzed after 5 days and 1 month, respectively, by detecting hu-α-syn pathology via immunofluorescence staining. B Real-time PCR results of cellular senescence markers (p16, Ki-67) and SASPs (IL-1α, IL-6) of young and aged mice (n = 6). C Following 5 days and 1 month post-injection, hu-α-syn diffused within the striatum (STR) of both young and aged mice. D Magnified representative image of hu-α-syn pathology distribution in injection site (STR injection, the remaining part of the STR [STR non-injection], cortex [CTX]) (scale bar: 50 μm). E Quantification and statistic results of hu-α-syn integrated density at 5 days and hu-α-syn pathology density in the STR and CTX at 1 month (n = 6). Values are presented as the means ± SEMs, and statistical significance was determined using the unpaired t-test *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. The arrow indicates hu-α-syn pathology.

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