Fig. 6: More hu-α-syn pathology accumulated in aged microglia after 1 month of intra-striatal hu-α-syn PFF injection. | Cell Death Discovery

Fig. 6: More hu-α-syn pathology accumulated in aged microglia after 1 month of intra-striatal hu-α-syn PFF injection.

From: Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction

Fig. 6

A Representative images showing the colocalization of hu-α-syn pathology and microglia (left) or astrocytes (right) in young and aged mice (scale bar: 50 μm). Brains were harvested 1 month after intra-striatal hu-α-syn PFF injection. B Quantification and statistical results of the percentage of hu-α-syn pathology-positive microglia in young and aged mice striatum (n = 6). C Quantification and statistical results of the number of microglia and astrocytes in young and aged mice after 1 month of intra-striatal hu-α-syn and PBS injection (n = 6). D Schematic picture illustrating that replicative glial passage induces replicative senescence, which shows characteristics of cellular senescence. Senescent glia shows prolonged hu-α-syn clearance via autophagy-lysosome system dysfunction. Values are presented as means ± SEMs and statistical significance was determined using the unpaired t-test (B) and two-way ANOVA with the Bonferroni test (C). **p < 0.01, ****p < 0.0001.

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