Fig. 1: MPTP induces AutD and the loss of TH+ neurons in the CNS. | Cell Death Discovery

Fig. 1: MPTP induces AutD and the loss of TH+ neurons in the CNS.

From: Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction

Fig. 1

A Experimental design of chronic MPTP mice model. MPTP (20 mg/kg) was injected twice a week for 5 weeks, the control group was injected with the same volume of saline, and CU-CPT22 (3 mg/kg) was injected daily for 35 days. B–J The quantitative analysis of 1 h fecal pellets, fecal water content, frequency of urination, average single urine volume, systolic pressure, diastolic pressure, heart rate, HF power, and the ratio of LF/HF in mice one week following the last MPTP injection. n = 8 per group. K, L Representative western blot bands and the quantitative analysis of TH level in the midbrain. n = 4 per group. M, N Representative immunohistochemical staining images of TH in the midbrain and striatum, and the quantitative analysis of the number of TH+ neurons in the midbrain, scale bar=200 μm for the left column in the midbrain, 100 μm for the right column in the midbrain and 200 μm in the striatum. n = 6 per group. Data were presented as mean ± SEM and analyzed using Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, AutD autonomic dysfunction, TH tyrosine hydroxylase, CNS central nervous system.

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