Fig. 1: Sub-FS stimuli may increase FS and epileptic susceptibility and promote neuronal injury. | Cell Death Discovery

Fig. 1: Sub-FS stimuli may increase FS and epileptic susceptibility and promote neuronal injury.

From: Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis

Fig. 1

A Experimental design. B Threshold dosages of PTZ at P14 (n = 6/group). C Threshold body temperature for induction of febrile seizures at P9 (n = 8/group). D, E Number of FJB-positive signals and representative images of FJB staining in the EC at 3 days (n = 4/group, scale bar = 50 μm). F–K Gray bands and normalized gray values of cleaved caspase-3 and caspase-3 relative to GAPDH at 3 days and 2 months (n = 4/group). Mean ± SEMs were presented. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group and #P < 0.05, ##P < 0.01 vs 41°C group (One-way ANOVA with LSD post-hoc test).

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