Fig. 1: LPS induces the activation of NLRP3 inflammasome and cardiac pyroptosis in rats. | Cell Death Discovery

Fig. 1: LPS induces the activation of NLRP3 inflammasome and cardiac pyroptosis in rats.

From: IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

Fig. 1

A The representative images of the left ventricle tissues of rats stained with HE (n = 6). B Apoptosis in myocardial tissues was detected by TUNEL staining (n = 6). C ELISA was used to detect serum BNP, IL-18 and IL-1β levels in the rats of each group (n = 6). D NLRP3, IL-18 and IL-1β mRNA levels were detected in the left ventricle tissues of rats using RT-qPCR analysis (n = 4). E Western blotting images and the summarized data showing NLRP3, GSDMD-FL, GSDMD-NT, Caspase-1 p10, IL-18 and IL-1β levels in the ventricular tissues of sham and LPS rats (n = 6). Data are shown as mean ± SEM. *P < 0.05, **P < 0.01.

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