Table 1 DAR evaluation by mass analysis of various trastuzumab constructs and payloads.

From: Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase

Antibody

Payload

Linker

DAR

Trastuzumab-Qtag2

Alexa 488-cadaverine

 

2

Trastuzumab-Qtag2

MMAE

PEG4-VC-PAB

1.5

TrastuzumabK453del-Qtag2

MMAE

PEG4-VC-PAB

1.74

Trastuzumab-Qtag2

DM1

PEG4-SMCC

1.25

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