Fig. 3: The prevention of Garcinol in oxidative stress-related bone loss in osteoporotic mice. | Cell Death Discovery

Fig. 3: The prevention of Garcinol in oxidative stress-related bone loss in osteoporotic mice.

From: Garcinol prevents oxidative stress-induced bone loss and dysfunction of BMSCs through NRF2-antioxidant signaling

Fig. 3

A The representative μCT images of mouse distal femurs from the CTL group, OVX group, OVX + 10 mg/Kg Garcinol group and OVX + 20 mg/Kg Garcinol group. B The trabecular structural parameters of mice were evaluated. C Garcinol inhibited the ROS level in BMSCs from osteoporotic mice. D Garcinol elevated the SOD level in BMSCs from OVX mice. N = 4. The comparisons among groups were analyzed by ANOVA analysis. **P < 0.01, ***P < 0.001 and ****P < 0.0001 vs. the CTL group. #P < 0.05, ##P < 0.01 and ####P < 0.0001 vs. the OVX group. μCT microcomputed tomography, BV/TV bone volume to tissue volume, Tb.N trabecular number, Tb.Sp trabecular separation, Tb.Th trabecular thickness, BMD bone mineral density, SMI structure model index, ROS reactive oxygen species, SOD superoxide dismutase.

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