Fig. 7: Potential application of the MACC1-AS1/STK33 signaling axis in pancreatic cancer animal and cell models. | Cell Death Discovery

Fig. 7: Potential application of the MACC1-AS1/STK33 signaling axis in pancreatic cancer animal and cell models.

From: LncRNA MACC1-AS1 induces gemcitabine resistance in pancreatic cancer cells through suppressing ferroptosis

Fig. 7

A–D The tumor volume, survival time, tumor photo and tumor weight were measured from the animal model injected with overexpression of MACC1-AS1 and control PANC-1 cells, with the treatment of Gemcitabine on the 7th day. E, F PANC-1 and PANC-1/Gem cells were co-transfected with the indicated vectors/MACC1-AS1/si-STKSS/ML281(treatment) and scramble/si-MACC1-AS1/STK33, by treated with Gemcitabine at different concentrations, after which cell viability was measured by CCK8 assay. G, H PANC-1 and PANC-1/Gem cells were co-transfected with the indicated scramble/MACC1-AS1/STKSS and scramble/si-MACC1-AS1/si-STK33, by treated with Gemcitabine at different hours, after which cell viability was measured by CCK8 assay. Data were represented as mean ± SD, *P < 0.05; **P < 0.01.

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