Fig. 4: AIM2 deficiency promotes both lipid accumulation and lipid peroxidation.
From: AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury
A GSEA Enrichment Score of KEGG pathways. B The heatmap of DEGs related to the ROS mechanism identified by Hallmark GSEA. Relative mRNA expression per row (red, high; blue, low). C, D Oil red O staining of liver segments from 6–8 and 30–32-week-old WT and AIM2−/− mice. Scale bar, 100 µm. E The liver homogenate content of TCs and TGs. n = 6 mice per group. F The serum MDA content and G the total liver GSH level in 30–32-week-old WT and AIM2−/− mice supplemented with PBS or APAP for 24 h. n = 8–10 mice per group. **P < 0.01; ***P < 0.001.
