Fig. 2: Dot plot visualization of sex-neutral changes in biological processes and molecular functions. | Cell Death Discovery

Fig. 2: Dot plot visualization of sex-neutral changes in biological processes and molecular functions.

From: Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer’s disease reveals sex-dependent dysregulations

Fig. 2

Dot plot displaying the most significant Gene Ontology biological processes (BP) in (A), and molecular functions (MF) in (B), enriched in THY-Tau22-associated sex-neutral DEGs. The radius of the circles reflects the number of genes linked to specific GO terms, and the color gradient from red to blue reflects the adjusted p-value (p.adjust, see right side legend). The horizontal axis represents the gene ratio, indicating the extent of overlap between the input DEGs and the members of the pathway, relative to the overlap with all the members in the gene set collection. Wherever possible, each plot has been sub-categorized into three different pathway alteration trends, up, down, and equal, depending on whether the majority of DEGs displayed over-expression or under-expression, or whether an equal number of genes occurred in both categories.

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