Fig. 7: Condition-specific gene regulatory networks enriched in male-specific DEGs. | Cell Death Discovery

Fig. 7: Condition-specific gene regulatory networks enriched in male-specific DEGs.

From: Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer’s disease reveals sex-dependent dysregulations

Fig. 7

Graph representation of the condition-specific Gene Regulatory Networks (GRNs) for two genotypes, THY-Tau22 (A) and wildtype (B), enriched in male-specific DEGs in cortical tissue. These networks depict the upstream regulatory genes and transcription factors, along with their interactions with direct downstream target genes. The THY-Tau22 network (A) consists of 4 genes and 5 interactions, while the wildtype network (B) comprises 9 genes and 9 interactions. In the graph, green lines represent activating interactions, red lines represent inhibitory interactions, and the node colors indicate the gene expression log fold change in the respective phenotype, transitioning from red (over-expressed) to blue (under-expressed).

Back to article page