Fig. 8: Condition-specific gene regulatory networks enriched in female-specific DEGs in brain microglial cells. | Cell Death Discovery

Fig. 8: Condition-specific gene regulatory networks enriched in female-specific DEGs in brain microglial cells.

From: Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer’s disease reveals sex-dependent dysregulations

Fig. 8

Graph representation of the condition-specific GRNs for two genotypes, THY-Tau22 (A) and wild type (B), enriched with female-specific DEGs in brain microglial cells. These networks depict the upstream regulatory genes and transcription factors, along with their interactions with direct downstream target genes (arrows pointing downwards). The THY-Tau22 network (A) consists of 32 genes and 37 interactions, while the wild-type network (B) comprises 32 genes and 40 interactions. In the graph, green lines represent activating interactions, red lines represent inhibitory interactions, and the node colors indicate the gene expression log fold change in the respective phenotype, transitioning from red (over-expressed) to blue (under-expressed) as shown in the color legend on the right.

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