Fig. 4: Tumor metastasis was promoted in an STK11^KO-cell-injected orthotopic mouse model of PDAC.

a Representative images of pancreatic tumors from the indicated group. b, c Resulting tumors were collected on day 21, measured, and weighed in comparison to the control group. Data are represented as the mean ± SD of at least four mice per group. ***p < 0.001; ****p < 0.0001 by one-way ANOVA. d Fisher’s exact t-test shows a significant difference in metastasis formation with STK11^KO cells (p < 0.001). e H&E staining was used to confirm the formation of metastases. Representative livers with metastases are shown. The arrows point to cancer cells in a metastatic lesion that surrounds normal liver tissue. Scale: 50 μm.