Fig. 4: miR-425-5p reverts MCT4-mediated metabolic shift resulting in reprogramming of Cancer-Associated Fibroblasts.

Metabolic changes in MCT4-transfected MS-5 cells with or without miR-425-5p overexpression, as assessed by glycolytic proton efflux rate (glycoPER) kinetics A, proton efflux rate (PER) B, extracellular acidification rate (ECAR) C, oxygen consumption rate OCR D, and ATP production E. Data are presented as a mean of biological duplicates of eight technical replicates ± SD over control.