Fig. 6: miR-425-5p overexpression in stromal fibroblasts modulates angiogenesis in the tumor microenvironment. | Cell Death Discovery

Fig. 6: miR-425-5p overexpression in stromal fibroblasts modulates angiogenesis in the tumor microenvironment.

From: MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p

Fig. 6

Representative images and quantifications of tube formation by HUVECs after culture in conditioned medium (CM) from miR-425-5p-overexpressing Cancer-Associated Fibroblasts (CAFs), compared to the control. 1 mM of lactate was used in rescue experiments A. Representative images and quantifications of tube formation by HUVECs cultured in CM from Normal Fibroblasts (NFs) with downregulated miR-425-5p, compared to the control. 1 mM of lactate was used in rescue experiments B. Data are presented as mean of six different images for each experimental point. * P values < 0.05; ** P values < 0.01; *** P values < 0.001. Bar = 500 μm.

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