Fig. 7: Schematic representation of miR-425-5p’s mechanisms of action. | Cell Death Discovery

Fig. 7: Schematic representation of miR-425-5p’s mechanisms of action.

From: MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p

Fig. 7

MiR-425-5p alters the metabolism of breast Cancer-associated Fibroblasts (CAFs) by downregulating MCT4 and indirectly reducing GLUT1, leading to decreased lactate extrusion. The interaction between miR-425-5p reprogrammed CAFs and breast cancer epithelial cells has a significant impact on breast cancer cell viability, proliferation, and migration. Angiogenesis is also influenced. This graphical abstract was drawn by using and adapting pictures from Servier Medical Art (Smart.Servier.com), provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license (http://creativecommons.org/licenses/by/3.0/).

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