Fig. 2: RIPK1 inhibitor ameliorates neutrophil infiltration and reduces the expression of chemokines in the lung tissue of ALI mice. | Cell Death Discovery

Fig. 2: RIPK1 inhibitor ameliorates neutrophil infiltration and reduces the expression of chemokines in the lung tissue of ALI mice.

From: RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Fig. 2

A, B Flow cytometry analysis of CD11b+Gr-1+ neutrophils in the lung (gated on FVDint viable single cells) and quantification analysis of neutrophils (% of total cell suspension). C The cell number of CD11b+Gr-1+ neutrophils in BALF by FACS. D MPO activity in the lung tissue was determined. E The production of LDH in serum was detected. Gene expressions of the adhesion molecules (F) and chemokines (G) were determined in lung tissue. n = 6 mice per group. All data are presented as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared to vehicle group. #P < 0.05, ##P < 0.01, ###P < 0.001 compared to normal group.

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