Fig. 1: NREP is upregulated and predicts poor prognosis value in BC patients. | Cell Death Discovery

Fig. 1: NREP is upregulated and predicts poor prognosis value in BC patients.

From: NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis

Fig. 1

A Venn diagram of 22 upregulated differentially expressed genes (DEGs) in nine BC databases from GEO. B Heat map of 22 DEGs in nine BC databases. C Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of 22 DEGs was analyzed by DAVIVD. D Gene ontology (GO) enrichment analysis of 22 DEGs was analyzed by DAVIVD. BP biological process, CC cellular component, MF molecular function. E The mRNA expression level of NREP in nine BC databases. T: tumor tissues; C: normal tissues. F The expression of NREP in the tumor, para-carcinoma, and healthy tissues of BC patients (analyzed by Breast Cancer Gene-Expression Miner v4.9). G Survival curves of BC patients with high or low NREP level (analyzed by Biomedical Informatics Institute). Overall survival (OS), metastasis-free survival (MFS), progression-free interval (PFI), and progression-free survival (PFS). H IHC staining of BC clinical samples with low or high NREP expression. Data were expressed as mean ± SD. *P < 0.05, **P < 0.01.

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