Fig. 5: NREP promotes BC tumor growth in vivo. | Cell Death Discovery

Fig. 5: NREP promotes BC tumor growth in vivo.

From: NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis

Fig. 5

A Tumor image of xenograft mice injected with NREP-shRNA or -OE infected MDA-MB-468 cells. B Tumor volume changes in the nude mice that were injected with NREP-shRNA or -OE infected MDA-MB-468 cells were analyzed over time. C, D The mRNA expression of NREP and Ki67 in mice formed tumor tissues was analyzed by qPCR. E, F The IHC images and positive cells of NREP and Ki67 in mice formed tumor tissues. G, H TUNEL staining images of mice formed tumor tissues. I IHC images of CD31 and microvessel density of mice formed tumor tissues. J, K The mRNA expression of E-cadherin and N-cadherin in mice formed tumor tissues was analyzed by qPCR. Data were expressed as mean ± SD. *P < 0.05, **P < 0.01.

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