Fig. 2: Overexpression of IGF2BP2 alleviated the severity of arthritis in CIA rats. | Cell Death Discovery

Fig. 2: Overexpression of IGF2BP2 alleviated the severity of arthritis in CIA rats.

From: IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis

Fig. 2

A The expression of IGF2BP2 was detected by western blotting in synovial tissues of rats after IGF2BP2 AAV treatment (n = 6 per group). B Representative photographs of morphology in different treatment groups. The arthritis index (C) and paw thickness (D) were scored and recorded every 7 days in a blinded manner. *Compared with CIA. (E, F) H&E and Safranin-O staining of the ankle in different groups. Scale Bar = 1600 µm. G, H qPCR analysis of the mRNA expression of IL-1β and IL-6 in different treatment groups. *P < 0.05, **P < 0.01, ***P < 0.001.

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