Fig. 1: IL-17 is associated with activated hepatic stellate cells. | Cell Death Discovery

Fig. 1: IL-17 is associated with activated hepatic stellate cells.

From: IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway

Fig. 1

A Representative immunohistochemical staining of α-SMA in cancer and adjacent tissues from five HCC patients. Magnification: 100×. B Positive correlation between IL-17+ cells and the integrated absorbance of α-SMA (r = 0.355, p < 0.001), according to immunohistochemical staining. C Heatmap of mRNA expression ratio of 12 hepatic stellate cell-related genes in cancer tissues compared to adjacent tissues of 60 HCC patients as determined by on-chip expression profiling. D Upregulation of FAP, SPARC, and TNC in patient cancer tissues compared to adjacent tissues. E Upregulation of FAP expression in tumor tissues (N = 369) compared to normal tissues (N = 160) in the LIHC cohort in the TCGA database. F Higher FAP expression was associated with worse overall survival in HCC patients. G mRNA expression of FAP in cancer and adjacent tissues of 60 HCC patients. H Western blot showing FAP expression in cancer and adjacent tissues of 12 HCC patients.

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