Fig. 7: IL-17 upregulates FAP expression by activating the p-STAT3 signaling pathway. | Cell Death Discovery

Fig. 7: IL-17 upregulates FAP expression by activating the p-STAT3 signaling pathway.

From: IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway

Fig. 7

A Protein levels of FAP, pSTAT3 (Tyr705), pSTAT3 (Ser727), and STAT3 after 20 ng/ml IL-17a stimulation or PBS treatment. B Protein levels of FAP, IL-17, ACTA2, and VIMENTIN in IL-17-OE cells, FAP-OE cells, and the corresponding negative control cell lines. C Protein levels of pSTAT3 (Tyr705), pSTAT3 (Ser727), STAT3, pP65, and P65 in IL-17-OE cells, FAP-OE cells, and the corresponding negative control cell lines. D The binding ability of pSTAT3 (Tyr705) and STAT3 to the FAP promoter region in FAP-OE and FAP-NC cells was evaluated by a CUT&RUN assay. E The binding ability of pSTAT3 (Tyr705) and STAT3 to the FAP promoter region in IL-17-OE and IL-17-NC cells was evaluated by a CUT&RUN assay. F The mRNA expression of FAP of LX2 cell line after 24 h treatment of 50 μg/mL Colivelin. G The expression of FAP, STAT3, and p-STAT3 in LX2 cell line after 24 h treatment of 50 μg/mL Colivelin. H The FAP, STAT3, p-STAT3 level in FAP-OE and FAP-NC cell lines after 2 μM HJC0152 treatment.

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