Fig. 5: Schematic illustration of the function of PGRN in lung cancer antitumor immunity. | Cell Death Discovery

Fig. 5: Schematic illustration of the function of PGRN in lung cancer antitumor immunity.

From: Deciphering the potential role of PGRN in regulating CD8+ T cell antitumor immunity

Fig. 5

Left: abnormally elevated PGRN levels in CD8+ T cells contribute to reduced CD8+ T-cell infiltration and function in TME due to suppressed CCL3 expression, leading to a “cold” tumor state resistant to immunotherapy. Right: PGRN knockout in CD8+ T cells promotes CCL3 production and improves CD8+ T-cell infiltration and function in TME, transforming the tumor into a “hot” state, enhancing sensitivity to immunotherapy, and restraining tumor growth.

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