Table 1 Ferroptosis induced by IR.

From: Role of ferroptosis in radiation-induced soft tissue injury

Organ	Pathway	Pathway target	Regulation by IR	Ferroptosis impact	Source(s)
Intestine	GPX4	GPX4, GSH	Down	Pro-ferroptotic	Zhang [52] Zhou [44] Ji [39]
	GPX4	GPX4, GSH	Unchanged	N/A	Wang [107]
	Iron metabolism	NCOA-mediated ferritinophagy, TfR1	Up	Pro-ferroptotic	Zhou [44]
		FPN, FTH, FTL	Down	Pro-ferroptotic	Zhou [44]
		Iron increase; cause unexplored		Pro-ferroptotic	Zhang [52] Wang [107],
	PUFA	ACSL4	Up	Pro-ferroptotic	Ji [39]
		ACSL4	Unchanged	N/A	Wang [107]
		Lipoxygenases (3, 5, 12b, 15)	Up	Pro-ferroptotic	Wang [107] Ji [39]
		LPCAT3	Up	Pro-ferroptotic	Wang [107]
Hematopoietic	GPX4	GPX4	Down	Pro-ferroptotic	Lopez-Nieva [64] Zhang [67] Zhang [42] Yin [66]^a Rittase [65]
		GSH	Down	Pro-ferroptotic	Zhang [67]
		SLC7A11	Down	Pro-ferroptotic	Lopez-Nieva [64]
		SLC7A11	Up	Protective	Rittase [65]
		SLC3A2	Down	Pro-ferroptotic	Yin [66]^a
	Iron metabolism	Hemorrhage	Up	Pro-ferroptotic	Zhang [42] Zhang [67] Rittase [65]
		TfR1	Down	Protective	Rittase [65] Yin [66]^a
		FPN	Up	Protective	Rittase [65] Zhang [42]
		FTH1	Up	Protective	Rittase [65]
			Down	Pro-ferroptotic	Yin [66]^a
			Unchanged	N/A	Zhang [67]
		IRP1/2	Down	Protective	Zhang [42]
		Iron decrease; cause unexplored		Protective	Li [56]
	PUFA	ACSL4	Down	Protective	Zhang [67] Yin [66]^a
	PUFA	15-LOX	Down	Protective	Zhang [67]
Lung	GPX4	GPX4	Down	Pro-ferroptotic	Liu [69] Li [73] Li [70] Li [56] Guo [71]
		GPX4	Unchanged	N/A	Ji [39]
		GSH	Down	Pro-ferroptotic	Li [56] Li [70]
		SLC7A11	Down	Pro-ferroptotic	Guo [71]
	Iron metabolism	Iron increase; cause unexplored		Pro-ferroptotic	Liu [69] Li [70]
	PUFA	ACSL4	Up	Pro-ferroptotic	Li [56] Liu [69]
		ACSL4	Unchanged	N/A	Guo [71] Ji [39]
		3-LOX, 5-LOX	Up	Pro-ferroptotic	Ji [39]
		15-LOX	Unchanged	N/A	Ji [39]
Skin	GPX4	GPX4, GSH	Down	Pro-ferroptotic	Jiang [38]
	GPX4	SLC7A11	Unchanged	N/A	Jiang [38]
	Iron metabolism	FTH1	Down	Pro-ferroptotic	Jiang [38]
	PUFA	ACSL4	Up	Pro-ferroptotic	Jiang [38]
Cardiovascular	GPX4	GPX4, GSH, NRF2, SLC7A11, SLC3A2	Down	Pro-ferroptotic	Wu [45]
Cardiovascular	Iron metabolism	NCOA4-mediated ferritinophagy	Up	Pro-ferroptotic	Wu [45]
Ovarian	GPX4	GPX4, GSH	Down	Pro-ferroptotic	Zhao [53]
	Iron metabolism	TfR1	Up	Pro-ferroptotic	Zhao [53]
	Iron metabolism	FPN	Down	Pro-ferroptotic	Zhao [53]
Brain	GPX4	GPX4, SLC7A11	Down	Pro-ferroptotic	Ren [48]
Brain	Iron metabolism	TfR1	Up	Pro-ferroptotic	Ren [48]

LOX lipoxygenase, FPN ferroportin, TfR1 transferrin receptor 1, FTH ferritin heavy chain, FTL ferritin light chain, SLC7A11 solute carrier family 7 member 11, SLC3A2 solute carrier family 3 member 2, GPX4 glutathione peroxidase 4, GSH glutathione, NCOA4 nuclear receptor coactivator 4.
^aHormesis response observed by Yin et al. at low doses; effects listed in the table are for radiation doses less than 4.8 gy, while effects were opposite for doses above 4.8 gy [66].

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Table 1 Ferroptosis induced by IR.

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