Table 3 Exogenous antioxidants inhibitors of IR-induced ferroptosis.
From: Role of ferroptosis in radiation-induced soft tissue injury
Organ | Intervention | Model organism | Primary mechanism | Reference |
|---|---|---|---|---|
Intestine | Ferrostatin-1 (Fer-1) | Rat (IEC-6 cells) | ROS scavenge/GPX4 upregulation | Wang [105] |
Liproxstatin-1 (Lip-1) | Rat (IEC-6 cells) | ROS scavenge/GPX4, GSH upregulation | Zhang [100] | |
Liproxstatin-1 | Mouse | ROS scavenge/LPCAT3, 15-LOX inhibition | Wang [107] | |
Lung | Ferrostatin-1 | Mouse | ROS scavenge/GPX4 upregulation | Li [70] |
SOD@ARA290-HBc | Mouse | ROS scavenge/anti-apoptosis / anti-inflammatory | Liu [69] | |
Liproxstatin-1 | Mouse | ROS scavenge/Enhances NRF2 activity | Li [106] | |
Hematopoietic | Ferrostatin-1 | Mouse | ROS scavenge/GPX4 upregulation | Zhang [67] |
Skin | pMnSOD | Human keratinocytes (HaCaT); Rat | ROS scavenge | Wang [77] |
CNS | Vitamin E | Mouse (HT-22 hippocampal neurons) | ROS scavenge | Ren [33] |
