Table 4 Drugs with a primary mechanism targeting iron metabolism.
From: Role of ferroptosis in radiation-induced soft tissue injury
Organ | Intervention | Model organism | Primary mechanism | Reference |
|---|---|---|---|---|
Intestine | 3-methyladenine (3-MA) | Human (HIEC-6 cells) | Inhibits ferritinophagy | Zhou [44] |
Intestine | Deferoxamine (DFO) | Human (HIEC-6 cells); Mouse | Iron chelation/GPX4, GSH upregulation | Zhou [44] |
Ovary | Deferoxamine (DFO) | Human (KGN cells) | Iron chelation/GPX4, GSH upregulation | Zhao [53] |
