Fig. 1: PI3K/AKT/mTOR signaling in immunometabolism.
From: Immunometabolism in cancer: basic mechanisms and new targeting strategy
Upon receipt of upstream signals, the PI3K/AKT/mTOR pathway is activated by phosphorylation, acting on a series of downstream signaling molecules to promote the anabolism of fatty acids, nucleotides, proteins, lipids, glycogen, and effector functions of immune cells.
