Fig. 2: LKBI-AMPK signaling in immunometabolism.
From: Immunometabolism in cancer: basic mechanisms and new targeting strategy
AMPK can be activated directly by LKB1 or in response to increased intracellular Ca2+ and lower ATP levels, acting on a range of downstream signaling molecules to inhibit fatty acid synthesis, protein synthesis, gluconeogenesis, promote glucose uptake, promote autophagy, and maintain mitochondrial function.
