Table 1 Lipid peroxidation-related targets involved in ferroptosis and their associations with the pathogenesis of acute pancreatitis.

From: Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment

Effect

Molecule

Targets

Acute pancreatitis mechanisms

References

Support ferroptosis

ACSL4

Fatty acids

Calcium overload

[19, 20]

LPCAT3

Fatty acids

Calcium overload

[6, 25]

ALOX5

Fatty acids

Inflammation

[8, 33, 34]

PLOOH

ROS

Membrane damage

[8, 22, 35]

Inhibit ferroptosis

FSP1

CoQ10, NADPH, ESCRT-III

Ca2+,

Inflammation,

Membrane damage

[18, 39, 40]

NRF2

HO-1, NADPH

Lipid peroxidation

[12, 43, 44]

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