Table 2 ECM proteins and metalloproteinases mediating the biological processes leading to IBD.

From: Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease

Processes leading to IBD

ECM components involved

Ref

ECM fragmentation

MMP-2, MMP-8, MMP-9, MMP-12

[75, 131]

Recruitment and migration of immune cells

Laminin, HSPGs, MMP-8, MMP-9

[7, 60, 61, 131]

Activation of inflammatory cytokines and kinases

MMP-3, MMP-9, MMP-13

[75, 78, 131]

Wound healing

HSPGs, Fibronectin, Hyaluronan, MMP-2, MMP-10

[15, 65, 76]

Barrier permeability

MMP-2, MMP-7, MMP-9, MMP-12, MMP-13

[15, 75, 77, 125, 131, 132]

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