Fig. 8: SNHG1 knockdown suppressed tumor growth and reversed sunitinib resistance and autophagy. | Cell Death Discovery

Fig. 8: SNHG1 knockdown suppressed tumor growth and reversed sunitinib resistance and autophagy.

From: An oncogenic role of lncRNA SNHG1 promotes ATG7 expression and autophagy involving tumor progression and sunitinib resistance of Renal Cell Carcinoma

Fig. 8

Nude mice were injected subcutaneously with the stable ACHN-R cells transfected with vector or sh-SNHG12 (n = 8/group). From day 20, sunitinib was fed to mice every day. A Images of the xenograft tumors in different groups. B The tumor volume was measured in different groups. C The tumor weight was detected in different groups. D IHC analysis was conducted to test ATG7 expression in tumor tissues of nude mice. Scale bar, 25 μm. E The protein levels of autophagy-related molecules were assessed by western blot in tumor tissues of different groups. F Molecular mechanism diagram of SNHG1 in modulating RCC progression. Error bars stand for the mean ± SD of at least triplicate experiments. *P < 0.05, **P < 0.01.

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