Fig. 1: LRRC8s family in human cancers.
From: Interactomic exploration of LRRC8A in volume-regulated anion channels
A Differential expression of LRRC8s family in human cancers. LRRC8s multiple gene comparison was performed using TCGA and GTEx datasets and using the GEPIA database. Data were normalized as transcripts per kilobase million (TPM) values. TPM values were converted to log2-normalized transcripts per million [log2(TPM + 1)]. B Mutation frequencies of LRRC8s in 32 cancer studies were retrieved from cBioPortal (TCGA Pan-Cancer Atlas dataset). C Mutation frequencies of LRRC8A in 32 cancer studies were retrieved from cBioPortal (TCGA Pan-Cancer Atlas dataset). D Survival plots based on LRRC8A expression level in represented tumours were obtained through Kaplan–Meier analysis by sorting samples for high and low LRRC8A expression groups according to Survival Genie software. E The forest plot illustrates hazard ratio (HR) analyses. The results of the Wald test (HR P-value) and log-rank test (LR P-value) are also displayed. F LRRC8A correlated differentially expressed genes and related pathways. The top 25 positively LRRC8A co-expressed genes were mapped using the TCGA KIRC, LGG, SARC, COAD, HNSC, and PAAD datasets in the ULCAN database.
